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15 A study by Kim et al showed that the presence of CB symptoms, defined by either classic or SGRQ definitions, was an independent predictor of exacerbation frequency in long-term follow-up

ACS Chem Neurosci 8:14591464

Also, peroxides cause significant alterations in sperm configuration, particularly in the acrosomal area, and a severe reduction in sperm motility
Despite inosine inducing a substantial increase in serum UA, no significant reduction in the rate of disease progression was observed

Subjects not included but still participating in the cohort study at the initial time point for inclusion for this analysis were on average slightly older, had lower lung function and higher mean pack-years of smoking, and more were current smokers (Table E1)
