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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024

Anyone with Digestive Issues or Absorption Problems: People with gastrointestinal conditions like Crohns disease, IBS, or those who have had bariatric surgery may struggle to absorb B12 through food alone and could benefit from supplementation

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For comparison, combining multiple appetite-modifying agents often creates unpredictable effects on hunger, energy intake, and metabolic rate

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