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Compared with those in normal skin fibroblast subpopulations, the expression levels of senescence- and inflammation-associated genes, including p16 (also known as CDKN2A ), SFRP4 18 , IGF1 19 , and IL1R1 were increased in keloid mesenchymal fibroblasts, whereas CCND2 , IL-6 , CXCL3 , and IL1R1 were increased in keloid pro-inflammatory fibroblasts (Fig

Sun LZ, Elsayed S, Aasen TB, Van Do T, Aardal NP, Florvaag E, et al

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In contrast to these pharmacological effects in obesity, animal studies largely depict obesity-promoting effects of GIP and attribute the weight-regulating effects of GIP to CNS-GIPR signaling (14)