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Acidification can activate ASICs, leading to neuronal excitability, hyperalgesia, and the development of mechanical and thermal hypersensitivity [53,54]
Timing adjustments may help with certain side effects
The mechanisms of central sensitization are rely on the pathological changes, particularly alterations in synaptic plasticity changes, within the central nervous system
Liang S, Wang X, Piao M, Chen X, Wang Z, Li C, et al
