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[DOI] [PMC free article] [PubMed] [Google Scholar] Aldrich C., Leroux-Roels I., Huang K.B., Bica M.A., Loeliger E., Schoenborn-Kellenberger O., Walz L., Leroux-Roels G., von Sonnenburg F., Oostvogels L

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Cancer cells induce epigenetic reprogramming of cancer-associated fibroblasts (CAFs), transforming them into a persistently activated state that secretes large amounts of ECM, thereby forming a physical barrier that obstructs drug and immune-cell infiltration

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