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Abbreviations [ 18 F]FLT: Fluorothymidine F 18 ADC: Antibody drug conjugate AICARFTase: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase AML: Acute myeloid leukemia ATIC: inosine monophosphate cyclohydrolase BBB: Blood-brain barrier BLM: Bleomycin C1: one-carbon CAM: CAR T adaptor molecule CAR: Chimeric Antigen Receptor CFD: Cerebral Folate Deficiency CIC: human Capicua gene CRS: Cytokine release syndromes CSF: Cerebral spinal fluid DFS: Disease-free survival DOX: Doxorubicin FITC: Fluorescein isothiocyanate FR: Folate receptor GARFTase: Glycinamide ribonucleotide formyltransferase GPI: Glycosylphosphatidyl inositol IHC: Immunohistochemical JAK: Janus Kinase LRP2: Low Density Lipoprotein Receptor Related Protein 2 mAbs: Monoclonal antibodies MDR: Multidrug Resistance MTHFD: Methylene tetrahydrofolate dehydrogenase MTHFD2L: homologous to MTHFD2 MTHFR: Methylenetetrahydrofolate reductase MTX: Methotrexate MTX-PG: Methotrexate polyglutamates N4Py: N,N-bis (2-pyridylmethyl)-N-bis (2-pyridyl)-methylamine NIR: Near-infrared NMD: Nonsense-mediated mRNA decay OS: Overall survival PCFT: Proton-coupled folate transporter Pgp: P-glycoprotein PMX: Pemetrexed PtdCho: Phosphatidylcholine RA: Rheumatoid arthritis RFC: Reduced folate carrier SHMT: Serine hydroxymethyltransferase TAA: Tumor Associated Antigen TAMs: Tumor associated macrophages TCT: targeted chemotherapy or alternatively targeted conventional therapy THF: Tetrahydrofolate TS: Thymidylate synthase VDR: Vitamin D nuclear receptor References Ducker GS, Rabinowitz JD

Bargmann CI, Hung MC and Weinberg RA

Int J Reprod BioMed (IJRM)

Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency

Retatrutide, still in Phase 3 clinical trials at Eli Lilly, is being bought off WhatsApp groups and injected at home by people who cannot wait for the regulatory process to run its course (more on NYT)