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Both the innate and adaptive responses have a central role in the chronic tissue injury and epithelial damage that represent SLE (89, 90)

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Safety and precautions: Because pure bacteriostatic water is hypotonic, it should not be injected alone intravenously (doing so can cause red cell hemolysis)

Among several substrates some could be proteins with unusual N-terminal extensions, serving as substrates to specific proteases and ultimately undergo proteolytic processing to deliver multifunctional proteins
