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Together, these findings indicate that while strong oxidants, such as H 2 O 2 , favor irreversible thiol overoxidation and suppress disulfide chemistry, reactive nitrogen species provide a physiologically relevant pathway for disulphide cross-linking of TTR

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However, the functional and physiological relevance of class II GRX redox-activity remains unclear

A clinical trial in China reported that the administration of G-CSF-mobilized CD34 + HSPCs in patients with HBV-related DLC through the hepatic artery led to significant enhancements in serum ALB levels, prothrombin activity (PTA), MELD scores, and ChildPugh scores [60]

doi: 10.1073/pnas.1707840114 96 LiHLiQYuZZhouMXieJ