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486 Similarly, in CSCs, metformin, an inhibitor of mitochondrial complex I, when combined with JQ-1, a BET inhibitor, or LY294002, a PI3K inhibitor, has shown potential in preclinical models by simultaneously impairing mitochondrial respiration and indirectly suppressing glycolysis

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A free radical is any molecule capable of independent existence that contains an unpaired electron in an atomic orbital

Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells