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The importance of selenocysteine comes from its role in gene expression and activity of the Se-dependent enzyme, GSH-Px (Floh et al., 1997

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Schrauzer G.N

Figure 2 It has been hypothesized by certain researchers that there is an interaction between retinal macrophages and ferroptosis, given the resemblance in the functions of the macrophages and the traits of ferroptosis ( Macrophages phagocytosis contributes considerably to the removal of ferroptotic cells, which could release a DAMP called HMGB1 to activate and recruit macrophages, alerting immune defenses ( In the context of ferroptosis, either advanced glycosylation end-product specific receptor (AGER) or Toll-like receptors (TLR) on macrophages is required for DAMPs to mediate inflammation

Ferroptosis, a New Form of Cell Death Opportunities and Challenges in Cancer

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