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Injections : 1,000 mcg IM weekly or monthly depending on need [*]

Doses of vitamin B12 exceeding 10 mcg daily may produce a hematologic response in patients who have a folate deficiency

Elevated NNMT activity results in the depletion of nicotinamide and S-adenosylmethionine (SAM) , disrupting NAD+ biosynthesis and methylation processes essential for metabolic balance (Kraus D, 2014)

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