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too little may not offer the desired therapeutic benefit

A B12 deficiency can cause demyelination, leading to neuropathy with neurological signs like numbness, pins and needles, and muscle weakness, especially in the feet and hands

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Endocrinology (1994) 134(5):204450.10.1210/endo.134.5.7512496 236 FichterMMPirkeKMHolsboerF

While it doesn't necessarily ruin the product, it indicates degradation, so airless pump packaging is highly recommended