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Description
This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017
doi: 10.1158/1078-0432.CCR-05-1830

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Therefore, GPX4 is key to cell survival (Friedmann Angeli et al., 2019)
