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There have been isolated reports of reversible hepatic injury following intravenous glutathione administration, emphasizing the need for careful monitoring, especially with repeated or high-dose therapy

This localized malabsorption can lead to a functional B12 deficiency, even if dietary intake appears adequate

3.1.5 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disease caused by pathogenic variants in the nuclear TYMP gene encoding the thymidine phosphorylase enzyme (Nishino et al., 2000)

While early nonresponse is considered to be an indicator of later nonresponse and subsequent treatment resistance in schizophrenia [67], to our knowledge, the association between early nonresponse in first-episode samples and later sequential treatment failures and the status of conventionally defined TRS is yet to be established