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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression

that is, when pharmacokinetics are linear. In this situation, when the drug is eliminated (ie, metabolized and excreted from the body), the fall in blood level is proportionate to the concentration of the drug in blood

In naive animals, CBD has relatively mixed results with regards to its effects on memory

Animal Lifespan Studies Animal studies in rodents have shown remarkable lifespan extension effects

The formal review process is still underway, and the PCAC's recommendations are advisory, not binding