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A significant challenge lies in translating preclinical findings to human clinical trials, which require rigorous testing across diverse populations to confirm the clinical GlyT1 inhibition benefits in treating conditions such as schizophrenia, cerebral ischemia, Alzheimers disease, and addiction

Notably, the observed changes in ferroptosis-related markers in the DAPA group were consistent with those in the Fer-1 group

Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are the primary enzymatic antioxidants present in cells that help to protect cells from ROS-induced damage (Pizzino et al., 2017)

EGCg has been identified as the primary active ingredient responsible for green teas health-promoting effects

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