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doi: 10.1182/blood-2011-10-387969 [DOI] [PMC free article] [PubMed] [Google Scholar] 100

The overall effect is a self-limiting peel, that is more predictable to administer, for maximum results with limited unwanted side-effects

[] Similarly, dual inhibition of SHP2 and CDK4/6 has demonstrated efficacy in MPNST, offering a promising treatment strategy

While each approach has demonstrated promise in preclinical and early clinical studies, resistance mechanisms, off-target effects, and intratumoral heterogeneity continue to limit their widespread clinical success

2021;13:eabg8116
