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Preclinical studies have indicated the potential efficacy of this approach across a range of diseases, including ischemia-reperfusion injury, neurodegenerative disorders, kidney diseases, acute respiratory distress syndrome, and cancer [124, 138,139,140,141,142,143]
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In an in vitro model of neural stem cell-derived neurons (NSCN), ketamine has been reported to decrease the phosphorylation of glycogen synthase kinase 3 (GSK-3), which could lead to apoptosis [119]
Characterization of vimentin-immunoreactive astrocytes in the human brain
