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In terms of biochemistry, iron metabolism, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and accumulation of ROS in lipid peroxidation products collectively constitute the major features of ferroptosis

Besides, multiple NAD + -dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA, RNA and proteins, or releasing second messenger cyclic ADP-ribose (cADPR) and NAADP +

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It is intended exclusively for in vitro testing and laboratory experiments

Despite the heavy economic burden, cancer remains a complex global problem, and stands as the second leading cause of mortality in the United States, underscoring the complexity and pervasiveness of this disease (259)