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Table 2 Candidate biomarkers for cerebrospinal fluid in patients with PD

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Here, copper is transported through the portal system to the liver by binding to soluble chaperones such as human serum albumin (HSA), ceruloplasmin, histidine, and macroglobulin [19, 20]

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The decreased SAM : SAH ratio leads to an increase in CYP2E1, lipid peroxidation, the upregulation of ER stress marker genes, and prevention of DNA methylation (7679)