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Role of Adropin in cardiometabolic disorders: from pathophysiological mechanisms to therapeutic target

Most of the commonly used oxidoreductase assays for glutaredoxins are either discontinuous and labor-intensive or unidirectional and coupled to the glutathione reductase-dependent consumption of NADPH 1,2,6,8,16,17,18,30

This disruption results in the translocation of phosphatidylserine from the cytoplasm to the extracellular space, potentially leading to sustained lipid peroxidation of the membrane lipids and ultimately cell death, with CFTR playing a synergistic role in this process

E.SotirakoglouK.TavrizelouS.et al (2021)