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The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014

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Mechanistically, tirzepatide + 5-amino-1MQ should outperform semaglutide monotherapy, but individual response variability and lack of head-to-head data prevent definitive claims