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Furthermore, IL-6 may regulate metabolic reprogramming in chondrocytes, particularly affecting lipid and amino acid metabolism, through activation of the JAK STAT pathway, thereby influencing the synthesis and balance of GSH and NADPH

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For this purpose, antioxidant concentrations within the range used in cellular or biochemical applications were included in the assays

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Quercetin supplementation does not alter antioxidant status in humans

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doi: 10.4093/dmj.2019.0185

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