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Subsequently, it was found that individuals who are susceptible to hemolytic anemia display genetically inherited reduced activity of glucose-6-phosphate dehydrogenase (G6PDH), which catalyzes the first committed step in the PPP 2

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The transcription of ACSL4 is started by a cAMP-response element binding (CREB) site found in the proximal promoter region of the gene (57)

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The trials were conducted by randomly dividing people into different treatment groups receiving either clomiphene citrate or letrozole along with NAC or a placebo to compare the effectiveness of NAC (Table 1)