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glutathione natural news Glutathione, a Valuable Ally Against Oxidative Stress Tumor-targeted glutathione oxidation catalysis with
Description
An -hydroxy acid sometimes produced at high levels by cancer cells, which structurally resembles -ketoglutarate and so inhibits -ketoglutarate-dependent enzymes such as the Jumonji-family histone demethylases

GSTs are multifunctional enzymes that catalyze the conjugation of glutathione (GSH) to electrophilic compounds, including xenobiotics and reactive oxygen species (ROS), converting these into less toxic metabolites for excretion 49

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By altering the secretory profile of senescent cells, senomorphics can mitigate tissue inflammation and promote a microenvironment more conducive to regeneration, while preserving the beneficial growth-arrest functions of senescence

Nat Rev Neurol (2017) 14(1):5762
