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In TNBC xenograft models and basal-like breast cancer, CB-839, either alone or in combination with paclitaxel, exhibits a potent antitumor effect (Gross et al., 2014)

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Holzer M, Birner-Gruenberger R, Stojakovic T, El-Gamal D, Binder V, Wadsack C, Heinemann A, Marsche G

Preclinical studies report higher mitochondrial DNA copy numbers and elevated respiratory enzyme levels in muscle tissue, correlating with increased VOmax and reduced fatigue in rodent exercise tests

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