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The formation of ulcers often originates from a combination of peripheral arterial disease, the accumulation of excessive peroxides, an imbalance in oxidative stress that damages the microvasculature and accelerates cell apoptosis, diabetic neuropathy, foot infection and deformities where immediate treatment is mandatory to ensure efficient wound healing and closure

97 NishidaY.ItoS.OhtsukiS.YamamotoN.TakahashiT.IwataN.et al (2009)

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Polydopamine (PDA) has excellent biocompatibility and antioxidant capacity [109]
