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Description
Common upstream drivers in Hashimotos Gluten and cross-reactive foods in susceptible individuals Intestinal permeability (leaky gut) and mucosal barrier injury Dysbiosis (microbiome imbalance) and chronic GI inflammation Micronutrient deficits that impair antioxidant defense and immune regulation High stress physiology with poor sleep and autonomic dysregulation Infections that drive immune activation in genetically susceptible hosts Environmental toxins that increase inflammatory burden Gut health is central because a large portion of immune regulation occurs at the gut-immune interface
It remains to be elucidated to which extent and under which conditions the ectoenzymedependent (Figure 1) and independent pathways may contribute to the supply of cysteine for the GSH synthesis in neurons under physiological or pathological conditions

In addition, the RGC deaths in these mice are distributed across the whole retina, rather than in specific regions as seen in human glaucoma

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Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions
