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However, degradation rates can be increased by temperature changes occurring during transportation

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A treatment course of 4-8 weeks is typically recommended for best results, with ongoing assessments to evaluate effectiveness and decide whether to continue

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Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Manneras-Holm L, Sthlman M, Olsson LM, Serino M, Planas-Flix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernndez-Real JM, Bckhed F (2017) Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug