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The slight but significant effect on periosteal and appendicular skeletal growth could be seen at a much earlier postnatal age (about 23 weeks) in mice having a liver-specific double knockout of igf-1 and the ALS that display a 90% reduction in serum IGF-1 levels

S7A,D) mice and 8 months of age for GCLC floxed X GFAP-Cre mice (Fig

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