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This peroxide induced a concentration-dependent increase in [Ca 2+ ] i in C6 cells which was linear for the first 10 min after applying it (Figures 2A,B)
One study used supplemental precursor amino acids cysteine and glycine over a 14-day period to successfully restore glutathione synthesis and lower oxidative stress and oxidant damage
For this reason, 1800 mg bid was determined to be the maximum tolerated dose
Additionally, this study revealed that GSSSG treatment inhibited phosphorylation of transforming growth factor (TGF)--activated kinase 1 (TAK1)
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