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These findings suggest GPX4 expression increases in SN neurons with the development of neuromelanin and continues to increase as expression of TH is lost

Larimore et al., 2009)

Furthermore, as it will be further discussed, we have reported a neuroprotective role for IGFs associated to mitochondrial protection and antioxidant defenses in aging animals[5558]

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Fluorescence from the propidium iodide-DNA complex was measured with a FACSCalibur flow cytometer (Becton Dickinson)