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Free radicals are not sufficiently neutralized by antioxidants, whose reserves deplete with age, so it is beneficial to supplement antioxidants through diet
Lack of insulin receptor signaling in Leprechaunism may result in the rare event of an alive but severely small for gestational age baby that will only survive if treated with recombinant-IGF-1 to substitute inulin receptor signaling with IGF1R signaling via their common intracellular pathways
