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Front Cell Infect Microbiol 11:767845 Freitas DRJ, Rosa RM, Moraes J, Campos E, Logullo C, Da Silva Vaz I Jr, Masuda A (2007) Relationship between glutathione S-transferase, catalase, oxygen consumption, lipid peroxidation and oxidative stress in eggs and larvae of Boophilus microplus (Acarina: Ixodidae)

Also, the absence of cellular atypia and the predominance of perivascular orientation should favor the diagnosis of GME

At the same time, activation of the polyol pathway also depletes large amounts of nicotinamide adenine dinucleotide phosphate (NADPH) and GSH synthesis, which further weakens cellular antioxidant capacity and exacerbates the extent of OS ( The protein kinase C (PKC) pathway is also activated in response to OS