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Another study using well-differentiated primary hBECs from a COPD cohort at an airliquid interface (ALI) found that basolateral treatment with NAC following DEP exposure did not provide any significant therapeutic effects, but did show trends in reducing IL-8 secretion and antioxidant gene expression [54]

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These results suggest that TAX6 acts cellautonomously in the AWA neurons to promote pulsatile activity, exact adaptation, and habituation between consecutive pulses