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We've analyzed hundreds of research protocols exploring peptide combinations, and the gap between theoretical synergy and practical implementation comes down to three factors most researchers overlook: receptor interaction profiles, dose timing windows, and compound stability under co-administration

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Funding This study was supported by the Research Program from Jiangsu Commission of Health (H2018109 to XW), the National Natural Science Foundation of China (81972783 to XW), the Jiangsu Distinguished Medical Experts Program (to XW), the Jiangsu Health Innovation Team Program (to XM), the Jiangsu 333 Talent Project (to HL), and the Nantong Commission of Health (MA2021029 to LX)