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Physician 62 (2), 357368

5 In 1921, Russel Wilder first proposed that a ketone-producing diet could be as effective as fasting for the treatment of epilepsy, and coined the term ketogenic diet

SAM is the major methyl donor for multiple methylation reactions and thereby influences DNA/histone methylation status and inflammatory transcriptional programs ( Cysteine (Cys) is an important fulcrum of redox homeostasis

Animal studies show that giving low doses (1-10mcg/kg) of melatonin speeds up intestinal transit times, but higher doses (100-1000mcg/kg) slow transit time significantly.[ref] IBS is often accompanied by increased transit time (diarrhea) or slowed transit time (constipation)

Some ended up in the hospital