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Through miR-429 , Rg3 regulates genes associated with apoptosis in gastric cancer (AGSR-CDPP) cells resistant to cisplatin [662], regulates cancer cell apoptosis via the MEK signaling pathway in melanoma (A375.S2) cells [663], and promotes p53 demethylation and histone acetylation of p21 and p16 to enhance apoptosis of renal cell carcinoma cells [664]

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Tissue engineering: combining cells and scaffolds The objective of the field of neural tissue engineering is to utilize biomaterial scaffolds and cell-based strategies in combination to augment endogenous regeneration and/or to provide direct replacement of neural cells and circuitry

However, there is a paucity of studies examining IRI in VCA clinical usage