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Studies in Expert Opinion on Drug Delivery reveal intranasal delivery typically achieves a bioavailability of less than 5% in humans for most peptides
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Thus, besides the liver, the de novo biosynthetic pathway seems to be a more indirect mechanism contributing to system-wide NAD + levels, with most NAD + coming from the NAM salvage pathway (BOX 1)
Rodrigues, M., Ezzedine, K
doi: 10.3109/00207458708991805
