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In line with decreased expression of key enzymes involving -oxidation (Figure 3, A and B), metabolomic analysis demonstrated significantly decreased levels of multiple acyl-carnitine species, without alterations in free carnitine levels (Figure 4, EG)
Clinically, DFP, as an oral hydroxypyridone derivative, is used in the treatment of diseases such as Friedreich's ataxia and thalassemia (Aminzadeh-Gohari et al
doi: 10.1124/jpet.300.3.762
Vascular AGE-ing by methylglyoxal: The past, the present and the future
performed statistical analyses
