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Probe trials on day 9 consistently showed that high doses of Dihexa, regardless of administration method, significantly increased time spent in the target quadrant compared to scopolamine-impaired groups, indicating preserved learned task memory

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All RSD values were below 5%, meeting the acceptable criteria for methodological validation [21]

In the UPS, proteins are selectively marked by ubiquitination, the covalent addition of ubiquitin (Ub) molecules to lysine residues, which signals and targets the protein for proteolytic degradation by the 26S proteasome

Hyperglycemia is one of the typical features of DCD, which can promote the overexpression of lipid peroxides (LPO) and ROS, induce central oxidative stress to cause brain injury (8, 9)