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Studies have shown that caffeic acid can inhibit the expression of Keap1, reduce the stabilization of the Keap1 and Nrf2 complex, thereby activate Nrf2 and upregulate the expression of downstream antioxidant enzymes NQO1 and HO-1 (Pang et al., 2016)

Summary Keywords Parkinsons disease, metabolic sybdrome, diabetes, Obesity, GLP-1/GIP RA Citation Invernizzi F, Ciocca L, Contaldi E, Inverso D, Calandrella D, Mignone F, Barichella M, Isaias IU and Pezzoli G (2025) Metabolic Parkinsons disease

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In contrast, M1-like TAMs impose a ferroptosis-promoting environment through ferritin degradation (ferritinophagy), release of labile iron, production of nitric oxide and ROS, and secretion of pro-inflammatory cytokines that suppress SLC7A11 function and perturb GSH biosynthesis (75)

None of the participants experienced symptoms of fever, skin rash, nausea or vomiting, irritative urinary symptoms (urgency or frequency), or dyspareunia