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There are several possibilities: Some DNA lesions may be more difficult to reach for the DNA repair enzymes since the structure of chromatin could have an important influence on DNA repair kinetics (Wheeler and Wierowski 1983)
[DOI] [PMC free article] [PubMed] [Google Scholar] 250.Masson W, Lobo M, Siniawski D, Huerin M, Molinero G, Valero R and Nogueira JP
Due to its effects as a competitive inhibitor of numerous 2-oxoglutarate and Fe 2+ -dependent dioxygenases, succinate is referred to as an oncometabolite
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