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[DOI] [PMC free article] [PubMed] [Google Scholar] Higgins 2011a Higgins JPT, Green S (editors)

You may also experience numbness and tingling in the hands and feet, balance problems, memory loss and confusion

Screening average-risk adults for vitamin B 12 deficiency is not recommended

Metformin is the preferred initial glucose-lowering agent for treating type 2 diabetes mellitus (T2DM).1 With more than 80 million prescriptions for metformin filled per year, it is the most commonly used T2DM medication in the United States

The overall risk appears to be very low, but the theoretical concern necessitates appropriate patient selection and informed consent