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TB-500 has been characterised as reducing inflammatory cytokine production, modulating macrophage polarisation toward pro-repair phenotypes, and attenuating the fibrotic deposition that can impair functional tissue repair when the inflammatory phase is prolonged or dysregulated

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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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