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And yet, the research, while limited to preclinical models, shows intriguing patterns of restoration rather than replacement

Regulation of cell death: the calcium-apoptosis link

29, 973 (2014), Abstract Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy: M.V

Addressing its pharmacokinetic limitations and validating its efficacy in humans will be critical steps toward realizing its clinical utility

The authors discussed several factors that may potentially account for the lack of clinical effect, including insufficient butyrate dosing, the pH-dependent microencapsulation technology (potentially affecting the site of release), the absence of defined therapeutic targets for distal colonic butyrate concentrations, and the relatively short follow-up period