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Cytochrome c oxidase assembly factor 6 (COA6) functions as a thiol-disulfide oxidoreductase that reduces the formation of disulfide bonds between cysteine residues in two proteins involved in cytochrome c oxidase assembly, synthesis of cytochrome c oxidase1 (SCO1) and SCO2

Though because gut health influences nearly every system in the body, symptoms can be more nuanced

TSHA-102, the human-ready version, showed significant improvements in respiration, weight, survival, and motor function in Mecp2/y knockout mice, supporting its advancement to clinical trials for RTT (NCT05606614)

FSP1 maintains the lung tumor growth of GPX4 knockout H460 cells in tumor xenograft mouse models under the treatment of IKE (System Xc- inhibitor and ferroptosis inducer in vivo) [68, 70]

Discovery of c-di-AMP as a putative second messenger