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Funding This work was supported by the National Natural Science Foundation of China (Nos

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J Neuropathol Exp Neurol 77:443453 Seidel K, Schols L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rub U, Kruger R (2010) First appraisal of brain pathology owing to A30P mutant alpha-synuclein

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These alterations impact the functionality of various ion channels, including hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, L-type calcium channels, sodium channels, and potassium channels