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Talk to your doctor before starting if you: Are allergic to B12 Have optic nerve issues (optic atrophy) Have blood in urine or polycythemia Are pregnant, breastfeeding, or trying to conceive Have low iron or folate, or an active infection Dosage, Concentration, Route of Administration Dosage: Always follow the guidance of a licensed medical provider for the correct dosage

PLoS ONE 12 , e0186459 (2017)

PMC 277821

While diagnostic uses for measuring total hemoglobin mass or pulmonary diffusion capacity remain permitted, using CO to artificially increase oxygen-carrying capacity is now explicitly banned

Laboratory monitoring in clinical trials showed no adverse effects on liver enzymes, kidney function, or other organ systems