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Although the proposed adverse effects discussed above deserve scrutiny, a pre-clinical safety evaluation by Xu et al

compared a number of outcomes in a patient cohort of individuals with alcoholic polyneuropathy of a duration of less than two years who were treated with one of three formulations administered orally three times daily for 12 weeks: (A) B1 250 mg, B2 10 mg, B6 250 mg, B12 20 g

Journal of Chemical Information and Modeling 53 , 15631575 (2013)

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(2006, Journal of Bone and Mineral Research) demonstrated accelerated tendon-to-bone healing in rat rotator cuff models, and a 2003 study by Sikiric et al